Expanding the CRISPR toolbox by engineering Cas12a orthologs of metagenomic discovery
Dagang Tao, Bingrong Xu, Sheng Li, Hailong Liu, Suyu Shi, Yuan Wang, Changzhi Zhao, Jinxue Ruan, Liangliang Fu, Xingxu Huang, Xinyun Li, Shuhong Zhao, Shengsong Xie
The paper identifies and characterizes new Cas12a orthologs from metagenomic data, leading to variants with improved PAM recognition and editing efficiency for CRISPR applications.
bioRxiv · Sep 27, 2024 · PreprintSynthetic Biology