Yuan Wang

This paper develops a CRISPR-based assay using Cas12a orthologs for detecting NDRV S3 gene with high sensitivity and visual detection capability.

This study identifies PYK2 as an immunomechanical checkpoint governing monocyte-to-macrohage differentiation in PDAC, showing its role in mechanotransduction and improved immunotherapy response.

The paper identifies and characterizes new Cas12a orthologs from metagenomic data, leading to variants with improved PAM recognition and editing efficiency for CRISPR applications.

PerturbAtlas re-analyzes 122,801 RNA-seq libraries to provide gene expression and splicing data from genetic perturbations across 13 species, enabling trend analysis and causal perturbation identification.

Sashimi.py provides a flexible and scalable tool for visualizing genomic data across multiple assays and formats, enabling combinatorial analysis of regulatory mechanisms.