Author

Changzhi Zhao

Huazhong Agricultural University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 1 Molecular Biology· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:benchmarking· 1 Assay:CRISPR screen· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:plant (other)· 1 Research Focus:protein structure prediction· 1 Approach:statistical model· 1

Frequent Co-Authors

Jinxue RuaniD· 3 shared Shuhong ZhaoiD· 3 shared Xinyun LiiD· 3 shared Bingrong XuiD· 2 shared Dagang Tao· 2 shared Hailong LiuiD· 2 shared Liangliang Fu· 2 shared Shengsong XieiD· 2 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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3 shared papersSynthetic Biology

Jinxue RuanORCID

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3 papers

Recent·Most cited

Expanding the CRISPR toolbox by engineering Cas12a orthologs of metagenomic discovery

Dagang Tao, Bingrong Xu, Sheng Li, Hailong Liu, Suyu Shi, Yuan Wang, Changzhi Zhao, Jinxue Ruan, Liangliang Fu, Xingxu Huang, Xinyun Li, Shuhong Zhao, Shengsong Xie

The paper identifies and characterizes new Cas12a orthologs from metagenomic data, leading to variants with improved PAM recognition and editing efficiency for CRISPR applications.

bioRxiv · Sep 27, 2024 · PreprintSynthetic Biology

Rapid visual CRISPR assay: a naked-eye colorimetric detection method for nucleic acids based on CRISPR/Cas12a and convolutional neural network

Shengsong Xie, Dagang Tao, Yuhua Fu, Bingrong Xu, You Xi Tang, Lucilla Steinaa, Johanneke Dinie Hemmink, Wenya Pan, Xin Huang, Xiongwei Nie, Changzhi Zhao, Jinxue Ruan, Yi Zhang, Jianlin Han, Liangliang Fu, , Shuhong Zhao

This paper develops a CRISPR/Cas12a-based colorimetric assay with a convolutional neural network for rapid, naked-eye detection of viral nucleic acids in point-of-care testing.

ACS Synthetic Biology · Dec 23, 2021Peer-reviewedMolecular Biology

CRISPR screening of porcine sgRNA library identified host factors essential for Japanese encephalitis virus replication

Changzhi Zhao, Hailong Liu, Tianhe Xiao, Zichang Wang, Xiongwei Nie, Xinyun Li, Ping Qian, Liuxing Qin, Xiaosong Han, Jinfu Zhang, Jinxue Ruan, Mengjin Zhu, Yi‐Liang Miao, Bo Zuo, Kui Yang, , Shuhong Zhao

The paper uses CRISPR screening in porcine cells to identify host factors essential for Japanese encephalitis virus replication and entry.

bioRxiv · Nov 13, 2019 · PreprintGenetics