Author

Jinxue Ruan

Huazhong Agricultural UniversityORCID 0000-0002-0058-6924Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Synthetic Biology· 2 Genetics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Assay:CRISPR screen· 2 Approach:experimental assay· 2 Research Focus:benchmarking· 1 Approach:deep learning· 1 Organism:Drosophila· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Organism:plant (other)· 1

Frequent Co-Authors

Changzhi Zhao· 3 shared Dagang Tao· 3 shared Shengsong XieiD· 3 shared Shuhong ZhaoiD· 3 shared Xinyun LiiD· 3 shared Bingrong XuiD· 2 shared Hailong LiuiD· 2 shared Liangliang Fu· 2 shared

Activity by Year

2019-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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3 shared papersSynthetic Biology

Changzhi Zhao

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4 papers

Recent·Most cited

A Rapid and Highly Sensitive CRISPR Assay Utilizing Cas12a Orthologs for the Detection of Novel Duck Reovirus

Yuan Wang, Lanting Fu, Sheng Li, Dagang Tao, Ping Gong, Yu Yang, Jinxue Ruan, Shengsong Xie, Cui Wang, Daqian He

This paper develops a CRISPR-based assay using Cas12a orthologs for detecting NDRV S3 gene with high sensitivity and visual detection capability.

Talanta · Aug 6, 2025Peer-reviewedSynthetic Biology

Expanding the CRISPR toolbox by engineering Cas12a orthologs of metagenomic discovery

Dagang Tao, Bingrong Xu, Sheng Li, Hailong Liu, Suyu Shi, Yuan Wang, Changzhi Zhao, Jinxue Ruan, Liangliang Fu, Xingxu Huang, Xinyun Li, Shuhong Zhao, Shengsong Xie

The paper identifies and characterizes new Cas12a orthologs from metagenomic data, leading to variants with improved PAM recognition and editing efficiency for CRISPR applications.

bioRxiv · Sep 27, 2024 · PreprintSynthetic Biology

Rapid visual CRISPR assay: a naked-eye colorimetric detection method for nucleic acids based on CRISPR/Cas12a and convolutional neural network

Shengsong Xie, Dagang Tao, Yuhua Fu, Bingrong Xu, You Xi Tang, Lucilla Steinaa, Johanneke Dinie Hemmink, Wenya Pan, Xin Huang, Xiongwei Nie, Changzhi Zhao, Jinxue Ruan, Yi Zhang, Jianlin Han, Liangliang Fu, , Shuhong Zhao

This paper develops a CRISPR/Cas12a-based colorimetric assay with a convolutional neural network for rapid, naked-eye detection of viral nucleic acids in point-of-care testing.

ACS Synthetic Biology · Dec 23, 2021Peer-reviewedMolecular Biology

CRISPR screening of porcine sgRNA library identified host factors essential for Japanese encephalitis virus replication

Changzhi Zhao, Hailong Liu, Tianhe Xiao, Zichang Wang, Xiongwei Nie, Xinyun Li, Ping Qian, Liuxing Qin, Xiaosong Han, Jinfu Zhang, Jinxue Ruan, Mengjin Zhu, Yi‐Liang Miao, Bo Zuo, Kui Yang, , Shuhong Zhao

The paper uses CRISPR screening in porcine cells to identify host factors essential for Japanese encephalitis virus replication and entry.

bioRxiv · Nov 13, 2019 · PreprintGenetics