Spatial transcriptomics reveals molecular dysfunction associated with Lewy pathology
Thomas M. Goralski, Lindsay K. Meyerdirk, Libby Breton, Laura Brasseur, Kevin Kurgat, Daniella DeWeerd, Lisa Turner, Katelyn Becker, Marie Adams, Daniel Newhouse, Michael X. Henderson
The paper uses spatial transcriptomics to identify specific cortical neurons vulnerable to Lewy pathology in PD and discovers a conserved molecular dysfunction signature in both mice and humans.
Nature Communications · Mar 26, 2024Peer-reviewedNeuroscience