Author

Daniella DeWeerd

Van Andel InstituteORCID 0000-0002-2675-5132Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Michael X. HendersoniD· 3 shared Danielle S. BassettiD· 2 shared Julia K. BrynildseniD· 2 shared Katelyn BeckeriD· 2 shared Kevin KurgatiD· 2 shared Laura BrasseuriD· 2 shared Lindsay K. MeyerdirkiD· 2 shared Lisa TurneriD· 2 shared

Activity by Year

2024-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersNeuroscience

Michael X. HendersonORCID

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3 papers

Recent·Most cited

Network analysis of α-synuclein pathology progression reveals p21-activated kinases as regulators of vulnerability

Naman Vatsa, Julia K. Brynildsen, Thomas M. Goralski, Kevin Kurgat, Lindsay K. Meyerdirk, Elizabeth Breton, Daniella DeWeerd, Laura Brasseur, Lisa Turner, Katelyn Becker, Kristin L. Gallik, Christine Isaguirre, Ryan D. Sheldon, Danielle S. Bassett, Michael X. Henderson

The paper identifies group II p21-activated kinases as regulators of α-synucleinopathy by linking network vulnerability analysis to gene expression and pharmacological interventions.

bioRxiv · Oct 22, 2024 · PreprintNeuroscience

Spatial transcriptomics reveals molecular dysfunction associated with Lewy pathology

Thomas M. Goralski, Lindsay K. Meyerdirk, Libby Breton, Laura Brasseur, Kevin Kurgat, Daniella DeWeerd, Lisa Turner, Katelyn Becker, Marie Adams, Daniel Newhouse, Michael X. Henderson

The paper uses spatial transcriptomics to identify specific cortical neurons vulnerable to Lewy pathology in PD and discovers a conserved molecular dysfunction signature in both mice and humans.

Nature Communications · Mar 26, 2024Peer-reviewedNeuroscience

LRRK2 kinase inhibition reverses G2019S mutation-dependent effects on tau pathology spread

Noah Lubben, Julia K. Brynildsen, Connor M. Webb, Howard Liu Li, Cheryl E. G. Leyns, Lakshmi N. Changolkar, Bin Zhang, Emily S. Meymand, Mia O’Reilly, Zach B. Madaj, Daniella DeWeerd, Matthew J. Fell, Virginia M.‐Y. Lee, Danielle S. Bassett, Michael X. Henderson

This study shows that LRRK2 kinase inhibition reverses tau pathology progression in mice with the G2019S mutation but not in wildtype mice.

Translational Neurodegeneration · Mar 4, 2024Peer-reviewedNeuroscience