Kevin Kurgat

Rise-and-fall dynamics reveal a molecular and cellular vulnerability axis in prion-like α-synuclein propagation

The paper analyzes longitudinal histopathology data to show that α-synuclein pathology follows rise-and-fall dynamics, revealing a vulnerability axis linked to energy metabolism and monoaminergic neurons.

Network analysis of α-synuclein pathology progression reveals p21-activated kinases as regulators of vulnerability

The paper identifies group II p21-activated kinases as regulators of α-synucleinopathy by linking network vulnerability analysis to gene expression and pharmacological interventions.

Spatial transcriptomics reveals molecular dysfunction associated with Lewy pathology

The paper uses spatial transcriptomics to identify specific cortical neurons vulnerable to Lewy pathology in PD and discovers a conserved molecular dysfunction signature in both mice and humans.

A topographical atlas of alpha-Synuclein dosage and cell-type expression in the mouse brain and periphery

This study maps the expression and dosage of alpha-Synuclein across cell types in the mouse brain and periphery, identifying high and low expressing cell types and their potential role in Parkinson's disease.