The breast tumor microenvironment exploits eosinophil plasticity to suppress their anti-tumor activity
Zofia Varyova, Mathilde Pohin, Gracie J. Mead, Libby K. Jennings, Valeria da Costa, Sarah Spear, Iain A. McNeish, Anja Schwenzer, Adrian Llewellyn Harris, Audrey Gérard, Kim S. Midwood
This study shows that the breast tumor microenvironment transforms eosinophils into a less active state by reducing Ly6C expression, impairing their anti-tumor function, and that IFN stimulation can partially restore this phenotype.
bioRxiv · Jan 12, 2026 · PreprintImmunology