Zofia Varyova

This study shows that PTEN's protein phosphatase activity is essential for embryonic development and tumor suppression in mice, as demonstrated by mutant mice with impaired protein phosphatase activity.

This study shows that the breast tumor microenvironment transforms eosinophils into a less active state by reducing Ly6C expression, impairing their anti-tumor function, and that IFN stimulation can partially restore this phenotype.

This study shows that a specific PTEN mutation causes macrocephaly, lymphoid overgrowth, and late-onset cancer in mice by impairing nuclear PTEN functions, while maintaining normal PI3K/AKT signaling.

The paper shows that IFN-gamma-insensitive tumours can still be controlled by immune responses, with IFN-gamma driving myeloid cell remodelling that enhances anti-tumour immunity.