Kim S. Midwood

The paper develops an in-silico pipeline to analyze degradomes from proteomic datasets, revealing disease- and endotype-specific tissue remodeling patterns in arthritis.

This study shows that the breast tumor microenvironment transforms eosinophils into a less active state by reducing Ly6C expression, impairing their anti-tumor function, and that IFN stimulation can partially restore this phenotype.

SpatioEv analyzes spatial data to reveal cell and neighborhood dynamics, identifying disease-specific spatial signatures and developmental trajectories in tissues.

Pathological epithelial GREM1 expression induces therapeutically reversible ectopic stem cell niches through stromal remodelling.

The paper shows that IFN-gamma-insensitive tumours can still be controlled by immune responses, with IFN-gamma driving myeloid cell remodelling that enhances anti-tumour immunity.

The paper uses multi-omic spatial analysis to identify fibroblast subsets in inflamed synovium that create tissue niches influencing immune cell trafficking and inflammation resolution.