Direct-to-Biology Enables Rapid Identification of Potent FBXO22 Degraders
Carla Brown, Sarvatit Patel, Lihi Habaz, Magdalena M. Szewczyk, Aiymzhan Istayeva, Peter Loppnau, Stuart Green, Joseph S. Brown, C.H. Arrowsmith, Dalia Barsyte-Lovejoy, Vijayaratnam Santhakumar
The paper tests PROTACs targeting FBXO22 and finds no degradation of four targets but identifies potent FBXO22 homo-PROTACs and CRBN/VHL-mediated degraders.
bioRxiv · Mar 2, 2026 · PreprintCell Biology