Joseph S. Brown

The paper tests PROTACs targeting FBXO22 and finds no degradation of four targets but identifies potent FBXO22 homo-PROTACs and CRBN/VHL-mediated degraders.

PSMtags enhance peptide detection and sequence identification in proteomics, enabling 9-plexDIA and significantly increasing sample throughput.

This paper introduces a multimodal foundation model for predicting protein phenotypes using sequence, structure, and natural language, showing competitive performance and novel insights into disease-related proteins.

The paper synthesizes a 217 amino acid-long N-terminal domain of pyocin S2 using automated fast-flow peptide synthesis, achieving rapid production and selective uptake in Pseudomonas aeruginosa.