Author

Sarvatit Patel

University of TorontoORCID 0000-0002-3101-8380Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

Aiymzhan Istayeva· 2 shared Dalia Barsyte-LovejoyiD· 2 shared Magdalena M. SzewczykiD· 2 shared Vijayaratnam SanthakumariD· 2 shared C.H. ArrowsmithiD· 1 shared Carla BrowniD· 1 shared Christian CaoiD· 1 shared Dakota GustafsoniD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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2 shared papersCell Biology

Aiymzhan Istayeva

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3 papers

Recent·Most cited

Direct-to-Biology Enables Rapid Identification of Potent FBXO22 Degraders

Carla Brown, Sarvatit Patel, Lihi Habaz, Magdalena M. Szewczyk, Aiymzhan Istayeva, Peter Loppnau, Stuart Green, Joseph S. Brown, C.H. Arrowsmith, Dalia Barsyte-Lovejoy, Vijayaratnam Santhakumar

The paper tests PROTACs targeting FBXO22 and finds no degradation of four targets but identifies potent FBXO22 homo-PROTACs and CRBN/VHL-mediated degraders.

bioRxiv · Mar 2, 2026 · PreprintCell Biology

Determination of the cellular target engagement by direct-to-biology Cellular Thermal Shift Assay (CETSA)

Magdalena M. Szewczyk, Darshil Patel, Sarvatit Patel, Aiymzhan Istayeva, Robert A. Batey, Dalia Barsyte-Lovejoy, Vijayaratnam Santhakumar

This paper demonstrates a direct-to-biology CETSA approach to evaluate cellular target engagement without purification, showing unpurified compounds can be used for assessment.

bioRxiv · Mar 2, 2026 · PreprintCell Biology

Multiomics unveils extracellular vesicle-driven mechanisms of endothelial communication in human carotid atherosclerosis

Sneha Raju, Mandy E. Turner, Christian Cao, Majed Abdul-Samad, Neil Punwasi, Mark C. Blaser, Rachel M. E. Cahalane, Steven R. Botts, Kamalben Prajapati, Sarvatit Patel, Ruilin Wu, Dakota Gustafson, Natalie J. Galant, Lindsey K. Fiddes, Melody Chemaly, , Kathryn L. Howe

This study identifies EV-driven endothelial communication in human carotid atherosclerosis, showing increased angiogenic activity in symptomatic plaques.

Arteriosclerosis Thrombosis and Vascular Biology · May 29, 2025Peer-reviewedCell Biology