Author

Aiymzhan Istayeva

University of Toronto

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2

Frequent Co-Authors

Dalia Barsyte-LovejoyiD· 2 shared Magdalena M. SzewczykiD· 2 shared Sarvatit PateliD· 2 shared Vijayaratnam SanthakumariD· 2 shared C.H. ArrowsmithiD· 1 shared Carla BrowniD· 1 shared Darshil Patel· 1 shared Joseph S. BrowniD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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2 shared papersCell Biology

Dalia Barsyte-LovejoyORCID

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2 papers

Recent·Most cited

Direct-to-Biology Enables Rapid Identification of Potent FBXO22 Degraders

Carla Brown, Sarvatit Patel, Lihi Habaz, Magdalena M. Szewczyk, Aiymzhan Istayeva, Peter Loppnau, Stuart Green, Joseph S. Brown, C.H. Arrowsmith, Dalia Barsyte-Lovejoy, Vijayaratnam Santhakumar

The paper tests PROTACs targeting FBXO22 and finds no degradation of four targets but identifies potent FBXO22 homo-PROTACs and CRBN/VHL-mediated degraders.

bioRxiv · Mar 2, 2026 · PreprintCell Biology

Determination of the cellular target engagement by direct-to-biology Cellular Thermal Shift Assay (CETSA)

Magdalena M. Szewczyk, Darshil Patel, Sarvatit Patel, Aiymzhan Istayeva, Robert A. Batey, Dalia Barsyte-Lovejoy, Vijayaratnam Santhakumar

This paper demonstrates a direct-to-biology CETSA approach to evaluate cellular target engagement without purification, showing unpurified compounds can be used for assessment.

bioRxiv · Mar 2, 2026 · PreprintCell Biology