In Vivo CRISPR Gene Editing in Patients with Herpes Stromal Keratitis
Anji Wei, Di Yin, Zimeng Zhai, Sikai Ling, Huangying Le, Lijia Tian, Jianjiang Xu, Søren R. Paludan, Yujia Cai, Jiaxu Hong
This study evaluates the safety and efficacy of in vivo CRISPR gene editing targeting HSV-1 in patients with herpes stromal keratitis, finding no detectable off-target effects or adverse events over 18 months.
medRxiv · Feb 21, 2023 · PreprintGenetic & Genomic Medicine