Søren R. Paludan

This study shows that DNA- and RNA-sensing immune pathways differently control genital HSV-2 infection and prevent neuroinvasion.

The paper investigates the role of STING in Parkinson's disease by comparing motor behavior and brain pathology in STING-deficient and wild-type mice exposed to alpha-synuclein fibrils.

This study shows that MECP2 inhibits cGAS signaling by exporting to the cytosol upon dsDNA detection, dampening inflammation and antiviral responses.

This paper uses single-cell proteomics by mass spectrometry (SCP-MS) to analyze mouse kidney cells, revealing previously undetected protein-level heterogeneity, including a proliferative subset of distal convoluted tubule cells.

This study uses single-cell RNA sequencing to analyze the temporal cellular responses in the brain during HSV-1 infection, identifying distinct immune cell subpopulations and their roles in both protective and pathological processes.

The paper characterizes satellite glial cell (SGC) subtypes in mouse and human dorsal root ganglia using single-cell RNA sequencing and spatial techniques, revealing distinct functional roles and spatial organization.

This study evaluates the safety and efficacy of in vivo CRISPR gene editing targeting HSV-1 in patients with herpes stromal keratitis, finding no detectable off-target effects or adverse events over 18 months.

This paper improves prime editing by modifying the reverse transcriptase component to enhance efficiency and enable delivery via split AAV vectors.