Glycemia Shift Pancreatic Islets Rhythmicity via δ-α Cell in vivo, Impairment in Diabetes
Yawen Deng, Zhengju Fu, Xuejiao Wang, Yongxing Qiao, Xi Wu, Sen Yang, Chunmei Zhou, Wenlong Huang, Lijing Hui, Weiran Qian, Liangyi Chen, Chao Tang, Yuanyuan Du, Xiaohong Peng, Huixia Ren
This study shows that glycemia shifts induce a coordinated change in pancreatic islet Ca2+ oscillations, mediated by δ- and α-cells, which is impaired in diabetes.
bioRxiv · Aug 9, 2025 · PreprintPhysiology