Weiran Qian

δ-α cell-to-cell interactions modulate pancreatic islet Ca2+ oscillation modes

The paper shows that δ-cell interactions modulate pancreatic islet Ca2+ oscillation patterns through somatostatin secretion and pharmacological/optogenetic perturbations, revealing a Hopf bifurcation mechanism.

Glycemia Shift Pancreatic Islets Rhythmicity via δ-α Cell in vivo, Impairment in Diabetes

This study shows that glycemia shifts induce a coordinated change in pancreatic islet Ca2+ oscillations, mediated by δ- and α-cells, which is impaired in diabetes.

Bright and sensitive red voltage indicators for imaging action potentials in brain slices and pancreatic islets

The paper introduces two red-emitting genetically encoded voltage indicators (GEVIs) that improve sensitivity, brightness, and photostability for imaging action potentials in brain slices and pancreatic islets.

A toolkit of highly selective and sensitive genetically encoded neuropeptide sensors

The paper develops GRAB sensors for detecting neuropeptides with high specificity and sensitivity, enabling in vivo monitoring of their release and function.