Huixia Ren

The paper shows that δ-cell interactions modulate pancreatic islet Ca2+ oscillation patterns through somatostatin secretion and pharmacological/optogenetic perturbations, revealing a Hopf bifurcation mechanism.

The paper uses imaging mass cytometry to analyze pancreatic duct-associated endocrine cells across age groups, finding changes in cell types and abundance linked to diabetes, obesity, and aging.

This study identifies a size-dependent trajectory of islet remodeling in T2D, showing medium and large islets correlate with glycemic failure while small islets show compensatory responses.

This study shows that glycemia shifts induce a coordinated change in pancreatic islet Ca2+ oscillations, mediated by δ- and α-cells, which is impaired in diabetes.

This study shows that somatostatin acting on primary cilia of pancreatic β-cells modulates cAMP and Ca2+ signaling, affecting β-cell function and linking cilia length to type-2 diabetes.

This paper develops a novel peripherally acting alpha2A-adrenergic receptor antagonist, CDS479-2, which improves glucose control in diabetic mice without central side effects.

The paper introduces two red-emitting genetically encoded voltage indicators (GEVIs) that improve sensitivity, brightness, and photostability for imaging action potentials in brain slices and pancreatic islets.

The paper develops GRAB sensors for detecting neuropeptides with high specificity and sensitivity, enabling in vivo monitoring of their release and function.

The paper shows that pancreatic α and β cells exhibit globally phase-locked Ca2+ oscillations with tunable phase shifts that set islet oscillation patterns.

Cellbow is a neural-network-based cell segmentation tool that achieves accurate and robust segmentation of diverse cell types in both fluorescent and bright-field images.