Oxidative DNA lesions destabilize centromeres and drive chromosome instability
Lily Thompson, Rim Nassar, Annapaola Angrisani, Owen Ou Ning Hsiu, Yian Yang, Katarzyna M. Kedziora, Daniela Muoio, Daniele Fachinetti, Wayne Stallaert, Elise Fouquerel
This study shows oxidative DNA damage destabilizes centromeres, leading to chromosome instability and mitotic defects in pre-tumorigenic cells.
bioRxiv · May 1, 2026 · PreprintCell Biology