Wayne Stallaert

The paper introduces SPInfer, a workflow for spatial proteomic inference that improves cell segmentation in human brain tissue, enabling better biological discovery at population scale.

This study shows oxidative DNA damage destabilizes centromeres, leading to chromosome instability and mitotic defects in pre-tumorigenic cells.

The paper identifies two distinct p21-driven pathways to whole-genome duplication in breast cancer cells, both converging on a CDK4/6-dependent polyploid G0 state, and shows that CDK4/6 inhibitors can block WGD and enhance therapy efficacy.

This study identifies NuRD complex downregulation and altered proteostasis in quiescent ovarian cancer cells and shows that targeting these mechanisms can synergistically kill cancer cells.

This paper introduces DELVE, a feature selection method that improves trajectory inference by identifying dynamically expressed features that better represent biological processes in single-cell data.

The paper identifies how EGFR interacts with PTPs on juxtaposed membranes to create a network that senses and responds to growth factor signals.