Author

Yian Yang

University of PittsburghORCID 0000-0002-0177-9170Unclaimed ORCID profile · follow to get notified of new preprints

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Yian Yang1 paper

Biology Disciplines

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Cell Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Assay:proteomics· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Katarzyna M. KedzioraiD· 2 shared Wayne StallaertiD· 2 shared Annapaola AngrisaniiD· 1 shared Anuraag BukkuriiD· 1 shared Daniel D. BrowniD· 1 shared Daniela MuoioiD· 1 shared Daniele FachinettiiD· 1 shared Dante PoeiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersCell Biology

Katarzyna M. KedzioraORCID

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2 papers

Recent·Most cited

Oxidative DNA lesions destabilize centromeres and drive chromosome instability

Lily Thompson, Rim Nassar, Annapaola Angrisani, Owen Ou Ning Hsiu, Yian Yang, Katarzyna M. Kedziora, Daniela Muoio, Daniele Fachinetti, Wayne Stallaert, Elise Fouquerel

This study shows oxidative DNA damage destabilizes centromeres, leading to chromosome instability and mitotic defects in pre-tumorigenic cells.

bioRxiv · May 1, 2026 · PreprintCell Biology

Distinct p21 dynamics drive alternative routes to whole-genome duplication through a common CDK4/6-dependent polyploid G0 state

Yian Yang, Anuraag Bukkuri, Dante Poe, Janet McLaughlin, Sihan Hao, Daniel D. Brown, Katarzyna M. Kedziora, Wayne Stallaert

The paper identifies two distinct p21-driven pathways to whole-genome duplication in breast cancer cells, both converging on a CDK4/6-dependent polyploid G0 state, and shows that CDK4/6 inhibitors can block WGD and enhance therapy efficacy.

bioRxiv · Jan 15, 2026 · PreprintCell Biology