Site-Specific Nanobody Inhibitors of the Proteasomal Deubiquitinase UCH37
Yanfeng Li, Lin Hui Chang, Rishi S. Patel, Elizaveta I. Shestoperova, Jiale Du, Mohamed Salam, Andrew N. R. Doig, Chittaranjan Das, Eric R. Strieter
This paper develops two nanobody inhibitors of UCH37 to separately target its two Ub-processing activities, enabling their independent study.
bioRxiv · Aug 11, 2025 · PreprintBiochemistry