Author

Rishi S. Patel

Purdue University West LafayetteORCID 0000-0002-4159-113XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

Chittaranjan DasiD· 3 shared Daniel Patrick FlahertyiD· 2 shared Elizaveta I. ShestoperovaiD· 2 shared Eric R. StrieteriD· 2 shared Nipuni M. PannalaiD· 2 shared Alisha DhimaniD· 1 shared Andrew N. R. Doig· 1 shared Brittany L. Allen-PeterseniD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersBiochemistry

Chittaranjan DasORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Substrate biasing in UCHL5 proteoforms

Rishi S. Patel, Nipuni M. Pannala, Chih-Hsuan Lai, Manoj Kumar Sriramoju, Yongsheng Wang, Ting Cheng, Dabin Jung, Payam Kelich, Soroush Asadi, Elizaveta I. Shestoperova, Shalini Iyer, Emad Tajkhorshid, Daniel Patrick Flaherty, Eric R. Strieter, Shang‐Te Danny Hsu, Chittaranjan Das

This study identifies substrate biasing in UCHL5 proteoforms, showing N-terminal ubiquitination activates the enzyme toward monoubiquitin substrates and regulates debranching activity.

bioRxiv · Jul 16, 2026 · PreprintBiochemistry

Identification, optimization, and structural elucidation of chloroacetamide scaffold as covalent inhibitors for Ubiquitin C-terminal Hydrolase L3

Nagabhushana C. Beeralingappa, Mengyao Lu, Rishi S. Patel, Nipuni M. Pannala, Alisha Dhiman, Brittany N. Heil, Ryan D. Imhoff, Emily G. Smith, Mei B Bahler, Haley L Marsden, Brittany L. Allen-Petersen, Mike Wendt, Chittaranjan Das, Daniel Patrick Flaherty

This study identifies and optimizes a chloroacetamide scaffold as a covalent inhibitor for UCHL3, supported by structural and biochemical validation.

bioRxiv · May 29, 2026 · PreprintPharmacology & Toxicology

Site-Specific Nanobody Inhibitors of the Proteasomal Deubiquitinase UCH37

Yanfeng Li, Lin Hui Chang, Rishi S. Patel, Elizaveta I. Shestoperova, Jiale Du, Mohamed Salam, Andrew N. R. Doig, Chittaranjan Das, Eric R. Strieter

This paper develops two nanobody inhibitors of UCH37 to separately target its two Ub-processing activities, enabling their independent study.

bioRxiv · Aug 11, 2025 · PreprintBiochemistry