Eric R. Strieter

This study identifies substrate biasing in UCHL5 proteoforms, showing N-terminal ubiquitination activates the enzyme toward monoubiquitin substrates and regulates debranching activity.

This paper develops two nanobody inhibitors of UCH37 to separately target its two Ub-processing activities, enabling their independent study.

This paper introduces a computational and experimental method to determine ubiquitin site and chain topology on proteins using top-down mass spectrometry.