Chittaranjan Das

This study identifies substrate biasing in UCHL5 proteoforms, showing N-terminal ubiquitination activates the enzyme toward monoubiquitin substrates and regulates debranching activity.

This study identifies and optimizes a chloroacetamide scaffold as a covalent inhibitor for UCHL3, supported by structural and biochemical validation.

This paper develops two nanobody inhibitors of UCH37 to separately target its two Ub-processing activities, enabling their independent study.