MG2Act: A Mechanism-Inspired Sequential Attention Framework for Molecular Glue Degradation Prediction
Zhiyao Zhuang, Dan Teng, Xiaojing Xu, Senbiao Fang, Yifan Wang, Menglu Hou, Ling Ge, Shanwen Yuan, Miaoyuan Yang, Lei Cheng, Zongqun Zhang, Qi He, Zhuoyue Li, Ximing Xu, Shumin -Ma, , Chong Qin
MG2Act predicts molecular glue degradation by modeling sequential interactions between E3 ligase and substrate, outperforming baselines and identifying new degraders.
bioRxiv · Aug 17, 2026 · PreprintBioinformatics