Macrophage renewal in the small intestine governs early-life control of streptococci
Zohreh Mansoori Moghadam, Mirjam Freudenhammer, Maria Francesca Viola, Marleen Eckert, Céline Raynaud, Linus Kriegl, Michael Rauer, Reem Alsumati, Nicole Simone Treichel, Ramona Rebekka Eckert, Sebastian Baasch, Melanie Boerries, Elvira Mass, Thomas Clavel, Daniel Erny, , Philipp Henneke
This study shows that small intestine macrophage dynamics control GBS colonization and invasion in infant mice, with region-specific responses to the pathogen.
bioRxiv · Feb 12, 2026 · PreprintImmunology