Canonical Notch2 Signaling Regulates the Development of Iron-recycling Macrophages and Iron Homeostasis
Frauline Nicole Schroth, Tamar Kapanadze, Stefan Sablotny…·Florian P. Limbourg
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University of BonnORCID 0000-0003-2318-2356Unclaimed ORCID profile · follow to get notified of new preprints
14 papers
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Frauline Nicole Schroth, Tamar Kapanadze, Stefan Sablotny…·Florian P. Limbourg
Miguel Mesquita, Maria V. Pires, Sara Nunes Violante…·Miguel Parreira Soares
This study identifies two anti-ferroptosis pathways in iron-recycling macrophages that prevent cell death and maintain iron homeostasis, revealing a key role for ferroptosis in iron deficiency anemia.
Zohreh Mansoori Moghadam, Mirjam Freudenhammer, Maria Francesca Viola…·Philipp Henneke
This study shows that small intestine macrophage dynamics control GBS colonization and invasion in infant mice, with region-specific responses to the pathogen.
Nikola Makdissi, DORIS J. HIRSCHMANN, A. N. FROLOV…·Elvira Mass
This study shows that yolk sac-derived Kupffer cells regulate neonatal hepatocyte metabolism via Igf1 signaling, essential for glycogen storage and TCA cycle function.
Tomi Lazarov, Pierre-Louis Loyher, Hairu Yang…·Frédéric Geissmann
The paper identifies a mesodermal progenitor in mouse gastrula and human iPSC cultures that gives rise to pro-definitive angio-hematopoietic lineage cells, including yolk sac endothelium, blood islands, and macrophages.
Katharina Sieckmann, Nora Winnerling, Dalila Juliana Silva Ribeiro…·Dagmar Wachten
This study shows that primary cilia dysfunction in Bbs8-/- mice reduces adipose stem cells and promotes fibrogenic progenitors via disrupted Hedgehog signaling, affecting adipogenesis and lipid uptake.
Lea Seep, Paul Jonas Jost, Clivia Lisowski…·Jan Hasenauer
cOmicsArt provides a customizable tool for omics analysis and reporting, integrating GUI-based analysis with R for reproducibility and customization.
Alexandre Gallerand, Zakariya Caillot, Frederike Westermann…·Stoyan Ivanov
The paper identifies CD226high macrophages derived from MDP monocytes as a new myeloid cell type involved in lipid metabolism regulation across tissues.
Tobias Beckröge, Bettina Jux, Hannah Seifert…·Waldemar Kolanus
This study shows that Trim71 deficiency during gastrulation disrupts gene expression, leading to defects in erythropoiesis and vascular development, causing embryonic lethality.
Amir Hossein Kayvanjoo, Iva Šplíchalová, David Alejandro Bejarano…·Elvira Mass
The paper identifies fetal liver macrophage subpopulations and shows their role in regulating granulopoiesis and the HSC niche during embryogenesis.
Lea Seep, Stephan Grein, Iva Šplíchalová…·Jan Hasenauer
This paper introduces Metadatasheet, a metadata standard designed to improve data management by aligning with the data-lifecycle and enabling structured metadata recording in Microsoft Excel.
Paul Kern, Nora Reka Balzer, Nelli Blank-Stein…·Elvira Mass
This study shows that Creld2 is essential for maintaining liver metabolism homeostasis by linking the unfolded protein response (UPR) to metabolic regulation, with sex-specific effects in fatty liver disease.
Nicolas Perrot, Donato Moschetta, S. Matthijs Boekholdt…·Benoît J. Arsenault
This study shows genetic inhibition of PCSK9 lowers lipoprotein levels and reduces risk of CAD and CAVS, with PCSK9 present in calcified aortic valves and induced by oxidative stress.