Altered liver metabolism post-wean abolishes efficacy of vitamin D for breast cancer prevention in a mouse model
Sarah M. Bernhardt, Michelle K. Ozaki, Courtney B. Betts, Lisa A. Bleyle, Andrea E. DeBarber, Jaime Fornetti, Abigail L. Liberty, Elise de Wilde, Yi Zhang, Zheng Xia, Pepper S. Schedin
This study shows that vitamin D's anti-cancer effects are reduced in post-wean mice due to altered liver metabolism, highlighting the importance of reproductive history in treatment efficacy.
bioRxiv · May 28, 2024 · PreprintCancer Biology