The Greatwall/PP2A-B55α axis remodels the G2/M boundary and shapes cellular dependence on PKMYT1
Róbert Zach, Alex Herbert, Calin-Mihai Dragoi, Megan Meredith, Lisandra Gadelkarim, William R. Foster, Helfrid Hochegger
The paper investigates how perturbations of the CDK1-Greatwall-PP2A-B55 feedback loop affect cell-cycle control in different cell types, finding that PP2A-B55 acts as a context-dependent G2/M repressor and that cancer cells show specific sensitivities to PKMYT1 inhibitors.
bioRxiv · Sep 8, 2026 · PreprintCell Biology