Author

Róbert Zach

University of SussexORCID 0000-0002-7604-1648Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 3

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Helfrid HocheggeriD· 3 shared Megan Meredith· 3 shared William R. FosteriD· 3 shared Alex HerbertiD· 2 shared Pedro R. CutillasiD· 2 shared Sandra M. Martín‐GuerreroiD· 2 shared Abdulrahman AlatawiiD· 1 shared Antony W. OliveriD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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3 shared papersCell Biology

Helfrid HocheggerORCID

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3 papers

Recent·Most cited

Greatwall Kinase regulates Acute Myeloid Leukaemia Cell Division through a Non-Canonical Mechanism

Sandra M. Martín‐Guerrero, Tommy Shields, Pedro Casado, Róbert Zach, Vinothini Rajeeve, Nadia Afroz-Nishat, Irbaz I. Badshah, Megan Meredith, William R. Foster, Helfrid Hochegger, Pedro R. Cutillas

This study shows Greatwall kinase regulates AML cell division through a non-canonical pathway distinct from its role in solid tumors.

EMBO Reports · Sep 30, 2026Peer-reviewedCell Biology

The Greatwall/PP2A-B55α axis remodels the G2/M boundary and shapes cellular dependence on PKMYT1

Róbert Zach, Alex Herbert, Calin-Mihai Dragoi, Megan Meredith, Lisandra Gadelkarim, William R. Foster, Helfrid Hochegger

The paper investigates how perturbations of the CDK1-Greatwall-PP2A-B55 feedback loop affect cell-cycle control in different cell types, finding that PP2A-B55 acts as a context-dependent G2/M repressor and that cancer cells show specific sensitivities to PKMYT1 inhibitors.

bioRxiv · Sep 8, 2026 · PreprintCell Biology

The Balance between B55α and Greatwall expression levels predicts sensitivity to Greatwall inhibition in cancer cells

Róbert Zach, Michael Annis, Sandra M. Martin-Guerrero, Abdulrahman Alatawi, Kim Hou Chia, Megan Meredith, Kay Osborn, Nisha Peter, William Pearce, Jessica Booth, Mohan B. Rajasekaran, Samantha Dias, Lily Coleman-Evans, William R. Foster, Jon Alexander Harper, , Helfrid Hochegger

This study shows that the balance between B55α and Greatwall expression levels determines cancer cell sensitivity to Greatwall inhibition.

Nature Communications · Aug 27, 2025Peer-reviewedCell Biology