Flexible pri-miRNA structures enable tunable production of 5' isomiRs
Xavier Bofill‐De Ros, Zhenyi Hong, Ben Birkenfeld, Sarangelica Alamo-Ortiz, Acong Yang, Lisheng Dai, Shuo Gu
The paper shows that flexible pri-miRNA structures enable the production of 5' isomiRs through alternative Drosha cleavage, influenced by RNA-binding proteins in cancer.
RNA Biology · Feb 19, 2022Peer-reviewedMolecular Biology