Author
Frederick National Laboratory for Cancer ResearchORCID 0000-0002-1630-0652Unclaimed ORCID profile · follow to get notified of new preprints
5 papers
Recent·Most cited
Acong Yang, Xavier Bofill‐De Ros, Ryan Stanton, Tiejuan Shao, Patricia Villanueva, Shuo Gu
The paper investigates how TENT2, TUT4, and TUT7 regulate miRNA 3' tailing, showing specific effects on sequence and abundance.
Nature Communications · Sep 7, 2022Peer-reviewedMolecular Biology
Xavier Bofill‐De Ros, Zhenyi Hong, Ben Birkenfeld, Sarangelica Alamo-Ortiz, Acong Yang, Lisheng Dai, Shuo Gu
The paper shows that flexible pri-miRNA structures enable the production of 5' isomiRs through alternative Drosha cleavage, influenced by RNA-binding proteins in cancer.
RNA Biology · Feb 19, 2022Peer-reviewedMolecular Biology
Xavier Bofill‐De Ros, Brian T. Luke, Robert Guthridge, Uma S. Mudunuri, Michael Loss, Shuo Gu
The paper introduces TIE, a database of miRNA isoforms from tumor samples, demonstrating their functional relevance and providing tools for analysis.
Bioinformatics · Mar 15, 2021Peer-reviewedGenomics
Thomas Desvignes, Phillipe Loher, Karen L Eilbeck, Jeffery Ma, Gianvito Urgese, Bastian Fromm, Jason Sydes, Ernesto Aparicio‐Puerta, Víctor Barrera, Roderic Espín, Florian Thibord, Xavier Bofill‐De Ros, Eric R. Londin, Aristeidis G. Telonis, Elisa Ficarra, , Lorena Pantano
The paper introduces mirGFF3, a standardized format for miRNA/isomiR analysis, and mirtop, a tool to convert outputs into this format, enabling data sharing and comparative analysis.
Bioinformatics · Aug 28, 2019Peer-reviewedBioinformatics
Xavier Bofill‐De Ros, Wojciech K. Kasprzak, Yuba R. Bhandari, Lixin Fan, Quinn Cavanaugh, Minjie Jiang, Lisheng Dai, Acong Yang, Tiejuan Shao, Bruce A. Shapiro, Yun‐Xing Wang, Shuo Gu
The paper shows that structural differences in pri-miRNA paralogs lead to alternative Drosha cleavage, generating miRNAs with expanded target repertoires and distinct roles in tumor progression.
Cell Reports · Jan 1, 2019Peer-reviewedMolecular Biology