Author

Lixin Fan

Frederick National Laboratory for Cancer ResearchORCID 0000-0002-9232-9262Unclaimed ORCID profile · follow to get notified of new preprints

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Lixin Fan2 papers

Biology Disciplines

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Biochemistry· 1 Bioengineering· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Approach:biophysical modeling· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Yun‐Xing WangiD· 2 shared Acong YangiD· 1 shared Anurag SinghiD· 1 shared Ashutosh ChilkotiiD· 1 shared Brent RungeiD· 1 shared Bruce A. ShapiroiD· 1 shared Diana C. F. MonteiroiD· 1 shared Erica Peng· 1 shared

Activity by Year

2019-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersBioengineering

Yun‐Xing WangORCID

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3 papers

Recent·Most cited

Intrinsically Disordered Protein Coating for Oral Delivery of Peptide Drugs

Max R. Ney, Parul Sirohi, Yulia Shmidov, Anurag Singh, Gable M. Wadsworth, Xinghai Li, James Zheng, Erica Peng, Lixin Fan, Tharun Selvam Mahendran, Sonal Deshpande, Navya Tripathi, Jonathan C. Su, Joshua J. Milligan, Yun‐Xing Wang, , Ashutosh Chilkoti

This paper introduces a synthetic intrinsically disordered protein coating that enhances oral delivery of peptide drugs by protecting them from gastric acid and enabling targeted intestinal release.

Cell Biomaterials · May 1, 2026Peer-reviewedBioengineering

A robust structural, kinetic and biophysical characterization of human ACOD1 to support novel chemotherapeutic development

Brent Runge, Hande Oktay, Ian J. Fucci, Sergey G. Tarasov, Lixin Fan, Diana C. F. Monteiro

This study provides structural, kinetic, and biophysical insights into human ACOD1 to support drug discovery for cancer and inflammatory diseases.

bioRxiv · Jun 13, 2025 · PreprintBiochemistry

Structural differences between pri-miRNA paralogs promotes alternative Drosha cleavage and expands target repertoires

Xavier Bofill‐De Ros, Wojciech K. Kasprzak, Yuba R. Bhandari, Lixin Fan, Quinn Cavanaugh, Minjie Jiang, Lisheng Dai, Acong Yang, Tiejuan Shao, Bruce A. Shapiro, Yun‐Xing Wang, Shuo Gu

The paper shows that structural differences in pri-miRNA paralogs lead to alternative Drosha cleavage, generating miRNAs with expanded target repertoires and distinct roles in tumor progression.

Cell Reports · Jan 1, 2019Peer-reviewedMolecular Biology