Structural differences between pri-miRNA paralogs promotes alternative Drosha cleavage and expands target repertoires
Xavier Bofill‐De Ros, Wojciech K. Kasprzak, Yuba R. Bhandari, Lixin Fan, Quinn Cavanaugh, Minjie Jiang, Lisheng Dai, Acong Yang, Tiejuan Shao, Bruce A. Shapiro, Yun‐Xing Wang, Shuo Gu
The paper shows that structural differences in pri-miRNA paralogs lead to alternative Drosha cleavage, generating miRNAs with expanded target repertoires and distinct roles in tumor progression.
Cell Reports · Jan 1, 2019Peer-reviewedMolecular Biology