Author

Xiaoyan Dong

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 1

Frequent Co-Authors

Yan Xia· 2 shared Yue Wang· 2 shared C E CheniD· 1 shared Congcong CheniD· 1 shared Dan He· 1 shared Hongze Niu· 1 shared Jia Chen· 1 shared Jianfang Zhou· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersGenetic & Genomic Medicine

Yan Xia

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2 papers

Recent·Most cited

GC801-enabled AAV gene therapy in a neonate with Pompe disease

Jia Chen, Wenhao Ma, 漆洪波, Xiuwei Ma, Yanmei He, Liu He, Yan Ke, Lu Zhuang, Xinyang Jiang, Jianhua Wang, Juan Xu, Yan Xia, Jianfang Zhou, Yue Wang, Xiaoyan Dong, , Zhichun Feng

This paper describes the use of GC801 to reduce anti-AAV9 antibodies in a neonate with Pompe disease, enabling successful AAV9 gene therapy.

medRxiv · Sep 29, 2026 · PreprintGenetic & Genomic Medicine

An engineered IdeS variant with enhanced activity and performance for IgG degradation

Keyi Zhang, Wenhao Ma, Zhijie Wu, Zipei Ren, Congcong Chen, Yan Xia, Dan He, Z-F Yu, Hongze Niu, Jing Qin, Pan Gao, WY Yang, Yangguang Dai, Xiu Li, Zheyue Dong, , XC Wu

This paper engineers an improved IgG-degrading enzyme, IdeSM33, showing enhanced activity and IgG depletion in vivo, with therapeutic potential for autoimmune diseases and gene therapy.

bioRxiv · Jul 1, 2026 · PreprintBioengineering