CTR1-mediated copper uptake orchestrates metabolic-epigenetic regulation of pathogenic TH17 cells in autoimmune disease
Lucile Noyer, Liwei Wang, Miki Jishage, Maxwell McDermott, Aidan T. Pezacki, Anthony Y. Tao, Ravichandran Ramasamy, Matthias Stadtfeld, Christopher J. Chang, Stefan Feske
This study shows that CTR1-mediated copper uptake is essential for pTH17 cell differentiation and function in autoimmune disease by linking copper homeostasis to metabolic and epigenetic regulation.
bioRxiv · Sep 28, 2026 · PreprintImmunology