Aidan T. Pezacki

This study shows that CTR1-mediated copper uptake is essential for pTH17 cell differentiation and function in autoimmune disease by linking copper homeostasis to metabolic and epigenetic regulation.

The paper investigates metal homeostasis changes in quiescent cells induced by different triggers and finds trigger-specific remodeling of metal pools and associated gene expression.

The paper shows liver-targeted copper supplementation reduces steatosis by enhancing lipolysis and fatty acid oxidation through copper-dependent metabolic pathways.

The paper shows that lysosomes in C. elegans expand to store zinc, copper, and manganese, with metal transporters localizing to both acidified and expansion compartments.

The paper shows that the PBAF chromatin remodeling complex regulates metal homeostasis in myoblasts via Mtf1, with metal supplementation compensating for some complex deficiencies.

This paper evaluates melatonin as a dual-function therapeutic for Wilson disease, showing it reduces copper toxicity and oxidative stress in vitro and in vivo.

This study shows that endothelial CTR1 senses disturbed flow by increasing mitochondrial copper, leading to cuproptosis and atherosclerosis, and identifies a therapeutic target.

This study identifies mCrip2 as a copper-responsive regulator of skeletal muscle differentiation through functional and biochemical analyses in murine myoblasts.

This paper identifies swip-10's role in systemic copper homeostasis in C. elegans, linking it to mitochondrial function, oxidative stress, and neurodegeneration.