Circular mRNA encoded PROTAC (RiboPROTAC) as a new platform for the degradation of intracellular therapeutic targets
Jiali Yang, Jiaojiao Sun, Jiafeng Zhu, Yaran Du, Yiling Tan, Lixiang Wei, Yang Zhao, Qiangbo Hou, Yan Zhang, Zhenhua Sun, Chijian Zuo
This paper introduces RiboPROTAC, a new platform using circular mRNA to degrade intracellular proteins, demonstrating its effectiveness in degrading GFP and PCNA with functional and immunological effects.
bioRxiv · Apr 22, 2022 · PreprintMolecular Biology