Clean-PIE: a novel strategy for efficiently constructing precise circRNA with thoroughly minimized immunogenicity to direct potent and durable protein expression
Zonghao Qiu, Qiangbo Hou, Yang Zhao, Jiafeng Zhu, Mengting Zhai, Daolei Li, Yi Li, Chunxi Liu, Na Li, Yifei Cao, Jiali Yang, Zhenhua Sun, Chijian Zuo
Clean-PIE generates high-purity, low-immunogenic circRNAs that enable durable protein expression in vitro and in vivo.
bioRxiv · Jun 20, 2022 · PreprintMolecular Biology