Yan Zhang

This study visualizes G2L4 reverse transcriptase's role in DNA repair via microhomology-mediated end joining using high-speed atomic force microscopy.

This study develops biosensors for MIAs and identifies metabolic engineering hits to enhance MIA production in yeast.

This paper introduces a deep learning model that predicts biological function from chemical structure using scientific literature, identifying effective inhibitors of beta-lactamases.

The paper defines the minimal sequence requirements of RNA polymerase II CTD across transcriptional stages using structural analysis and synthetic constructs, revealing a 'zipper' model for PIC assembly and transcription progression.

The paper introduces NitrOFF, a fluorescent biosensor for real-time nitrate detection in mammalian cells, showing it responds to nitrate with a turn-off fluorescence mechanism.

This study determines the structural basis for how a domesticated reverse transcriptase evolved to function in DNA repair by revealing key structural adaptations in its apoenzyme and DNA synthesis complexes.

This study identifies a mechanism where AMPK and cGAS-STING signaling synergize through glucose and dsDNA sensing to enhance antitumor immunity in melanoma and colorectal cancer.

The paper develops a method to detect combinatorial phosphorylation patterns on RNA polymerase II CTD and shows they recruit TREX for mRNA processing and export.

The paper develops a biosensor-AI system to engineer E. coli for efficient production of amaryllidaceae alkaloids, achieving improved titer and reduced byproducts.

This paper evolves highly specific and sensitive biosensors for alkaloids using a combined screening and selection approach, enabling improved microbial production of therapeutic plant metabolites.

This paper introduces RiboPROTAC, a new platform using circular mRNA to degrade intracellular proteins, demonstrating its effectiveness in degrading GFP and PCNA with functional and immunological effects.