In vivo isogenic modelling unveils TP53-associated relapse trajectories in T-cell acute lymphoblastic leukemia
Stéphanie Gachet, Samuel Quentin, Lucie Hernandez, Loïc Maillard, Marie Passet, Rathana Kim, Hugo Bergugnat, Melha Benlebna, Remy Jelin, Marine Aglave, Maxime Boy, Véronique Parietti, Pierre Fenaux, André Baruchel, Hervé Dombret, , Jean Soulier
This study uses patient-derived xenografts to identify TP53-associated relapse mechanisms in T-ALL, showing relapse phenotypes linked to OXPHOS metabolism and MYC signaling.
bioRxiv · Mar 16, 2026 · PreprintCancer Biology