Hugues de Thé

This study uses patient-derived xenografts to identify TP53-associated relapse mechanisms in T-ALL, showing relapse phenotypes linked to OXPHOS metabolism and MYC signaling.

This study shows that Pml loss worsens NEK1-linked ALS, while Pml induction reduces disease symptoms by clearing Nek1t aggregates.

The paper shows that PML/RARA fusion promotes hematopoietic progenitor immortalization via PML-driven sumoylation of NCoR, enhancing transcriptional repression and contributing to APL pathogenesis.

This study identifies Zbtb14 as a regulator of monocyte and macrophage development by inhibiting PU.1 expression in zebrafish, with implications for myeloid disorders.