Author

Pierre Fenaux

Assistance Publique – Hôpitaux de ParisORCID 0000-0002-0468-3553Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Pierre Fenaux1 paper · Adult Hematology Department, Saint-Louis Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France.

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Approach:benchmark study· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Olivier KosmideriD· 2 shared Achille AoubaiD· 1 shared Agnes J. VialeiD· 1 shared Akifumi Takaori‐KondoiD· 1 shared Alexandra Audemard‐VergeriD· 1 shared Alexandra G. SmithiD· 1 shared Alexis MathianiD· 1 shared André BarucheliD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersCell Biology

Olivier KosmiderORCID

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Author profile →

3 papers

Recent·Most cited

In vivo isogenic modelling unveils TP53-associated relapse trajectories in T-cell acute lymphoblastic leukemia

Stéphanie Gachet, Samuel Quentin, Lucie Hernandez, Loïc Maillard, Marie Passet, Rathana Kim, Hugo Bergugnat, Melha Benlebna, Remy Jelin, Marine Aglave, Maxime Boy, Véronique Parietti, Pierre Fenaux, André Baruchel, Hervé Dombret, , Jean Soulier

This study uses patient-derived xenografts to identify TP53-associated relapse mechanisms in T-ALL, showing relapse phenotypes linked to OXPHOS metabolism and MYC signaling.

bioRxiv · Mar 16, 2026 · PreprintCancer Biology

VEXAS anemia is a mosaic erythroblastopenia

François Rodrigues, Giulia Hardouin, Sara El Hoss, Aya Ghoul, Emilie‐Fleur Gautier, Michaël Dussiot, Maria A. Lizarralde-Iragorri, Annalisa Santini, Sandy Peltier, Pascal Amireault, Vanessa Soldan, Annarita Miccio, Mounia Debili, Vincent Jachiet, Thiago Trovati Maciel, , Jean‐David Bouaziz

This study investigates VEXAS anemia, showing that UBA1 mutations affect erythroblast differentiation but not mature red cells, leading to a mosaic erythroblastopenia.

Blood · Sep 19, 2025Peer-reviewedCell Biology

Implications of TP53 Allelic State for Genome Stability, Clinical Presentation and Outcomes in Myelodysplastic Syndromes

Elsa Bernard, Yasuhito Nannya, Robert Paul Hasserjian, Sean M. Devlin, Heinz Tuechler, Juan Santiago Medina-Martinez, Tetsuichi Yoshizato, Yusuke Shiozawa, Ryunosuke Saiki, Luca Malcovati, Max Fine Levine, Juan E. Arango, Yangyu Zhou, Francesc Gessé Solé, Catherine A. Cargo, , Elli Papaemmanuil

The paper examines TP53 allelic states in MDS patients, finding that bi-allelic targeting is linked to worse outcomes, while mono-allelic targeting does not differ from wild-type patients.

Nature Medicine · Aug 3, 2020Peer-reviewedGenomics