Two orthogonal MAP3K-driven pathways of NLRP1 inflammasome activation revealed by poisonous beetles.
Rae Chua, Stephen Wearne, Shirley Suet Lee Ding, Gee Ann Toh, Muhammad Jasrie Firdaus, Lim Ying Shiang, Chai Yoke Tin, Seong Soo Lim, Ray Putra Prajnamitra, Foo Siu Wen, Melina Setiawan, Loh Yan Ping, Lee Sze Han, John Common, Bin Wu, , Franklin L. Zhong
This paper identifies two distinct MAP3K pathways activated by beetle toxins that trigger NLRP1 inflammasome activation in human keratinocytes.
bioRxiv · Jan 25, 2026 · PreprintImmunology