Jiang-An Yin

PODXL regulates the neuronal entry of α-synuclein aggregates

This study identifies PODXL as a suppressor of α-synuclein fibril uptake in neurons, highlighting its glycan-dependent surface properties and interaction with MME.

Genome-wide arrayed CRISPR activation screen for prion protein modulators

The paper performs a genome-wide CRISPR activation screen to identify genes modulating PrPC abundance, finding 531 genes with significant effects and validating 45 of them.

Automation workflow for high-throughput arrayed plasmid DNA preparation and quantification.

The paper describes an automated workflow for high-throughput plasmid DNA preparation and quantification using a robotic workstation, achieving high yields and quality with minimal human intervention.

Automation of high-throughput workflow for arrayed CRISPR activation library screening

This paper develops an automated high-throughput workflow for arrayed CRISPRa screening, demonstrating its effectiveness in identifying growth reduction phenotypes in HEK293 cells.

Automation of high-throughput arrayed lentivirus production and titration

This paper develops an automated workflow for high-throughput lentivirus production and titration, achieving high reproducibility and efficiency in generating CRISPR libraries.

Automation of high-throughput arrayed mammalian cell line cultivation

This paper automates high-throughput mammalian cell culture workflows using an integrated workstation and software, enabling efficient clonal line establishment.