Tumour rewires host tryptophan metabolism to promote organism-wide immune suppression
Lucia García-López, Ernesto Saez-Carrion, Mary Luz Uribe, Carmen Gómez‐Escolar, Esther Ballesta‐Illán, Jason M. Tennessen, María Domínguez
This study shows that Pten-deficient Drosophila tumours reprogram host tryptophan metabolism to suppress immunity and promote tumour growth through the kynurenine pathway.
bioRxiv · Sep 3, 2026 · PreprintCancer Biology