Cellular Maturation of Oligodendrocytes is Governed by Transient Gene Melting
Kevin Cameron Allan, Tyler E. Miller, Andrew R. Morton…·Paul J. Tesar
This study identifies a transcriptional mechanism that controls oligodendrocyte maturation through SOX6-mediated gene melting, showing that suppressing SOX6 accelerates maturation and that an immature SOX6 signature is enriched in multiple sclerosis patient brains.