Marissa A. Scavuzzo

The paper uses snRNA-seq to analyze ileitis in SAMP mice, identifying stromal and epithelial transcriptional changes that mirror human CD, including Igf1 and Pcsk6 expression.

The paper identifies gut bacteria-derived succinate as a key metabolite that promotes enteric nervous system regeneration after antibiotic-induced dysbiosis.

This study identifies two classes of environmental chemicals that impair oligodendrocyte development through distinct mechanisms and links exposure to adverse neurodevelopmental outcomes.

The paper identifies specialized enteric glial cell subtypes in the mouse duodenum using single nucleus RNA-sequencing and spatial transcriptomics, showing one subtype's role in sensing force via PIEZO2 and its impact on gut motility.

This study identifies a transcriptional mechanism that controls oligodendrocyte maturation through SOX6-mediated gene melting, showing that suppressing SOX6 accelerates maturation and that an immature SOX6 signature is enriched in multiple sclerosis patient brains.

This study identifies non-canonical HIF1a targets that impair oligodendrocyte progenitor cell function and drive disease in chronic hypoxia.